Prevalence of HIV drug-resistance mutations in HIV-infected Mexican patients heavily experienced to antiretroviral therapy

Results We assessed 178 subjects, mean age (SD ±) of our subjects was 41.9 ± 11.9; 91% where male, who failed 2 to 15 ART regimen (median 5). CDC status was A 20%, B 21% and C 59%; 4% were coinfected with HBV and 2% were infected with HCV. Month median drug exposure was 121 (range 12-219). Ninety nine (55.6%) had triple class drug mutations, 170 (95.5%) had NRTI mutations, 113 (63.5%) had NNRTI mutations and 173 (97.2%) had PIs mutations. The most frequent NRTI mutation belonged to TAM pathways, 74 (41.6%) to TAM1 and 40 (22.5%) to TAM2. These mutations were 215Y/F 139 (77.7%), M41L 111 (62%), D67N 97 (54.2%), L210W 85 (47.5%), K219E/Q 60 (33.5%) and K70R 53 (29.6%) and reflect the extensive use of ZDV and d4T. K65R was found in 8 (4.4%), Q151M was found in 2 (1.1%) and insertion 69 in 1 (.5 %). The most frequent NNRTI mutation was K103N in 57 (31.8%) followed by Y181C 40 (22.3%), G190A/S 40 (22.3%), V108I 18 (10%), K101E 16 (8.9%), L100I 13 (7.3%), Y188L 11(6.1%), A98G 10(5.6%), V90I 9 (5%); 14 (8%) of them had resistance to ETV. Most common PI major mutation were L10V/F 144 (80%), I54L/M/V 126 (70.4%), M36I/L 102 (57%), L90M 101 (56%), 82A/T 92 (51.4%), M46I/L 91 (50.8%), L33F/I 69 (38.5%), I84V 64 (35%) and others. 15 (8.4%) of them had resistance to DRV and 33 (18.5%) to TPV.